Increased hypothalamic serotonin turnover in inflammation-induced anorexia.

ABSTRACT:

Background

Anorexia can occur as a serious complication of disease. Increasing evidence suggests that inflammation plays a major role, along with a hypothalamic dysregulation characterized by locally elevated serotonin levels. The present study was undertaken to further explore the connections between peripheral inflammation, anorexia and hypothalamic serotonin metabolism and signaling pathways. First, we investigated the response of two hypothalamic neuronal cell lines to TNFα, IL-6 and LPS. Next, we studied transcriptomic changes and serotonergic activity in the hypothalamus of mice after intraperitoneal injection with TNFα, IL-6 or a combination of TNFα and IL-6.

Results

In vitro, we showed that hypothalamic neurons responded to inflammatory mediators by releasing cytokin

SUBMITTER: Dwarkasing JT 

PROVIDER: S-EPMC4875640 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature