Apolipoprotein B is regulated by gonadotropins and constitutes a predictive biomarker of IVF outcomes.

ABSTRACT:

Background

Follicular fluid (FF) is an important micro-environment influencing oocyte growth, its development competence, and embryo viability. The FF content analysis allows to identify new relevant biomarkers, which could be predictive of in vitro fertilization (IVF) outcomes. Inside ovarian follicle, the amount of FF components from granulosa cells (GC) secretion, could be regulated by gonadotropins, which play a major role in follicle development.

Methods

This prospective study included 61 female undergoing IVF or Intra-cytoplasmic sperm injection (ICSI) procedure. Apolipoprotein B (APOB) concentrations in follicular fluid and APOB gene and protein expression in granulosa cells from reproductively aged women undergoing an in vitro fertilization program were measured. The

SUBMITTER: Scalici E 

PROVIDER: S-EPMC4875704 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature