New data from basal Australian songbird lineages show that complex structure of MHC class II β genes has early evolutionary origins within passerines.

ABSTRACT:

Background

The major histocompatibility complex (MHC) plays a crucial role in the adaptive immune system and has been extensively studied across vertebrate taxa. Although the function of MHC genes appears to be conserved across taxa, there is great variation in the number and organisation of these genes. Among avian species, for instance, there are notable differences in MHC structure between passerine and non-passerine lineages: passerines typically have a high number of highly polymorphic MHC paralogs whereas non-passerines have fewer loci and lower levels of polymorphism. Although the occurrence of highly polymorphic MHC paralogs in passerines is well documented, their evolutionary origins are relatively unexplored. The majority of studies have focussed on the more derived passe

SUBMITTER: Balasubramaniam S 

PROVIDER: S-EPMC4875725 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature