Development of a murine colonoscopic polypectomy model (with videos).

ABSTRACT:

Background and aims

Colonoscopy provides a means for screening and removal of colon adenomas, preventing such lesions from progressing to late-stage carcinoma. No preclinical model currently exists that closely parallels the clinical scenario with respect to polyp resection and recovery after endoscopy.

Methods

When we used the polyposis in rat colon (Pirc) model, a new polypectomy methodology was developed. A novel PLC classification system (polyp number/location/clockwise orientation) also was devised in order to accurately and reproducibly specify the location of each lesion within the colon.

Results

One week after surgery, injuries to the polypectomy site were confined to the submucosa, indicating that little or no damage occurred to the inner muscle layer of the

SUBMITTER: Ertem F 

PROVIDER: S-EPMC4875801 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature