Different evolutionary patterns of SNPs between domains and unassigned regions in human protein-coding sequences.

ABSTRACT: Protein evolution plays an important role in the evolution of each genome. Because of their functional nature, in general, most of their parts or sites are differently constrained selectively, particularly by purifying selection. Most previous studies on protein evolution considered individual proteins in their entirety or compared protein-coding sequences with non-coding sequences. Less attention has been paid to the evolution of different parts within each protein of a given genome. To this end, based on PfamA annotation of all human proteins, each protein sequence can be split into two parts: domains or unassigned regions. Using this rationale, single nucleotide polymorphisms (SNPs) in protein-coding sequences from the 1000 Genomes Project were mapped according to two classifications: S

SUBMITTER: Pang E 

PROVIDER: S-EPMC4875946 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature