Gene expression profile of THP-1 cells treated with heat-killed Candida albicans.

ABSTRACT:

Background

Mechanisms under immune response against Candida albicans (C. albicans) remain largely unknown. To better understand the mechanisms of innate immune response against C. albicans, we analyzed the gene expression profile of THP-1 cells stimulated with heat-killed C. albicans.

Methods

THP-1 cells were stimulated with heat-killed C. albicans for 9 hours at a ratio of 1:1, and gene expression profile of the cells was analyzed using Whole Human Genome Oligo Microarray. Differentially expressed genes were defined as change folds more than 2 and with statistical significance. Gene ontology (GO) and pathway analysis were used to systematically identify biological connections of differentially expressed genes, as well as the pathways associated with the immune response agai

SUBMITTER: Hu ZD 

PROVIDER: S-EPMC4876266 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature