Dynamic finite-element model for efficient modelling of electric currents in electroporated tissue.

ABSTRACT: In silico experiments (numerical simulations) are a valuable tool for non-invasive research of the influences of tissue properties, electrode placement and electric pulse delivery scenarios in the process of electroporation. The work described in this article was aimed at introducing time dependent effects into a finite element model developed specifically for electroporation. Reference measurements were made ex vivo on beef liver samples and experimental data were used both as an initial condition for simulation (applied pulse voltage) and as a reference value for numerical model calibration (measured pulse current). The developed numerical model is able to predict the time evolution of an electric pulse current within a 5% error over a broad range of applied pulse voltages, pulse duratio

SUBMITTER: Langus J 

PROVIDER: S-EPMC4876422 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature