Cerebral ischemia mediates the effect of serum uric acid on cognitive function.

ABSTRACT:

Background and purpose

High normal concentrations of serum uric acid (UA) are associated with mild cognitive dysfunction and increased cerebral ischemia as indexed by white matter hyperintensity volumes. We hypothesized that individual differences in white matter hyperintensities mediate the association between UA and mild cognitive dysfunction.

Methods

One hundred eighty community-dwelling adults aged 20 to 96 years completed neuropsychological testing, laboratory blood studies, and a brain MRI scan.

Results

Serum UA was associated (P<0.05) with greater white matter hyperintensities and poorer working memory, processing speed, fluency, and verbal memory. Associations remained after controlling for age, sex, race, education, hypertension, diabetes, alcohol abuse, smok

SUBMITTER: Vannorsdall TD 

PROVIDER: S-EPMC4876431 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature