The Association of Pre-S/S Gene Mutations and Hepatitis B Virus Vertical Transmission.

ABSTRACT:

Background

HBV Pre-S/S gene mutations can occur before or after implementation of combined vaccination program. HBV Prs-S/S gene mutation is a risk factor of vaccination failure and frequently causes HBV vertical transfection.

Objectives

To assess the association of hepatitis B virus (HBV) S gene mutations with vertical transmission.

Patients and methods

In this prospective nested case-control study, a total of 60 pregnant women with positive serum HBsAg and HBV DNA ≥ 10(7) IU/mL were divided into a case group (15 cases with vaccination failure) and a control group (45 cases with vaccination success) according to whether their infants tested positive for HBV infection. Mothers and their children in the case group were further sub-divided into groups including mothers,

SUBMITTER: Yin Y 

PROVIDER: S-EPMC4876664 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature