Poring over two-pore channel pore mutants.

ABSTRACT: Two-pore channels are members of the voltage-gated ion channel superfamily. They localise to the endolysosomal system and are likely targets for the Ca²⁺ mobilising messenger NAADP. In this brief review, we relate mutagenesis of the TPC pore to a recently published homology model and discuss how pore mutants are informing us of TPC function. Molecular physiology of these ubiquitous proteins is thus emerging.

SUBMITTER: Penny CJ 

PROVIDER: S-EPMC4876920 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature