Changes in the Adult GluN2B Associated Proteome following Adolescent Intermittent Ethanol Exposure.

ABSTRACT: Adolescent alcohol use is the strongest predictor for alcohol use disorders. In rodents, adolescents have distinct responses to acute ethanol, and prolonged alcohol exposure during adolescence can maintain these phenotypes into adulthood. One brain region that is particularly sensitive to the effects of both acute and chronic ethanol exposure is the hippocampus. Adolescent intermittent ethanol exposure (AIE) produces long lasting changes in hippocampal synaptic plasticity and dendritic morphology, as well as in the susceptibility to acute ethanol-induced spatial memory impairment. Given the pattern of changes in hippocampal structure and function, one potential target for these effects is the ethanol sensitive GluN2B subunit of the NMDA receptor, which is known to be involved in synaptic p

SUBMITTER: Swartzwelder HS 

PROVIDER: S-EPMC4877005 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature