Improved detection of disease-associated variation by sex-specific characterization and prediction of genes required for fertility.

ABSTRACT: Despite its great potential, high-throughput functional genomic data are rarely integrated and applied to characterizing the genomic basis of fertility. We obtained and reprocessed over 30 functional genomics datasets from human and mouse germ cells to perform genome-wide prediction of genes underlying various reproductive phenotypes in both species. Genes involved in male fertility are easier to predict than their female analogs. Of the multiple genomic data types examined, protein-protein interactions are by far the most informative for gene prediction, followed by gene expression, and then epigenetic marks. As an application of our predictions, we show that copy number variants (CNVs) disrupting predicted fertility genes are more strongly associated with gonadal dysfunction in male and

SUBMITTER: Ho NR 

PROVIDER: S-EPMC4877036 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature