The Lancet Weight Determines Wheal Diameter in Response to Skin Prick Testing with Histamine.

ABSTRACT:

Background

Skin prick test (SPT) is a common test for diagnosing immunoglobulin E-mediated allergies. In clinical routine, technicalities, human errors or patient-related biases, occasionally results in suboptimal diagnosis of sensitization.

Objective

Although not previously assessed qualitatively, lancet weight is hypothesized to be important when performing SPT to minimize the frequency of false positives, false negatives, and unwanted discomfort.

Methods

Accurate weight-controlled SPT was performed on the volar forearms and backs of 20 healthy subjects. Four predetermined lancet weights were applied (25 g, 85 g, 135 g and 265 g) using two positive control histamine solutions (1 mg/mL and 10 mg/mL) and one negative control (saline). A total of 400 SPTs were conducte

SUBMITTER: Andersen HH 

PROVIDER: S-EPMC4877047 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature