Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity.

ABSTRACT: Whereas cancers grow within host tissues and evade host immunity through immune-editing and immunosuppression, tumours are rarely transmissible between individuals. Much like transplanted allogeneic organs, allogeneic tumours are reliably rejected by host T cells, even when the tumour and host share the same major histocompatibility complex alleles, the most potent determinants of transplant rejection. How such tumour-eradicating immunity is initiated remains unknown, although elucidating this process could provide the basis for inducing similar responses against naturally arising tumours. Here we find that allogeneic tumour rejection is initiated in mice by naturally occurring tumour-binding IgG antibodies, which enable dendritic cells (DCs) to internalize tumour antigens and subsequently

SUBMITTER: Carmi Y 

PROVIDER: S-EPMC4877172 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature