Women with preterm birth have a distinct cervicovaginal metabolome.

ABSTRACT:

Objective

Metabolomics has the potential to reveal novel pathways involved in the pathogenesis of preterm birth (PTB). The objective of this study was to investigate whether the cervicovaginal (CV) metabolome was different in asymptomatic women destined to have a PTB compared with term birth.

Study design

A nested case-control study was performed using CV fluid collected from a larger prospective cohort. The CV fluid was collected between 20-24 weeks (V1) and 24-28 weeks (V2). The metabolome was compared between women with a spontaneous PTB (n = 10) to women who delivered at term (n = 10). Samples were extracted and prepared for analysis using a standard extraction solvent method. Global biochemical profiles were determined using gas chromatography/mass spectrometry and ultr

SUBMITTER: Ghartey J 

PROVIDER: S-EPMC4877183 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature