Sequencing of mutational hotspots in cancer-related genes in small cell neuroendocrine cervical cancer.

ABSTRACT:

Objectives

Small cell cervical cancer is a rare malignancy with limited treatment options for recurrent disease. We sought to determine if tumor specimens of small cell cervical cancer harbor common somatic mutations and if any of these are actionable.

Methods

Using a registry of patients with neuroendocrine cervical cancer, we identified 44 patients with pure or mixed small cell cervical cancer who had undergone mutational analysis. Mutations had been detected using next generation sequencing of mutational hotspots in 50 cancer-related genes.

Results

Thirty-five mutations were identified in 24 patients (55%). Fifteen of these 24 patients (63%) had 1 mutation, 7 patients (29%) had 2 mutations, and 2 patients (8%) had 3 mutations. In all 44 patients, the most commonly

SUBMITTER: Frumovitz M 

PROVIDER: S-EPMC4877250 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature