Impact of statin use on survival in patients undergoing resection for early-stage pancreatic cancer.

ABSTRACT:

Objectives

It has been suggested that statins exert potential anti-tumor effects. The relationship between statin use and outcomes in pancreatic cancer is controversial. We hypothesized that statin use at baseline would impact survival among patients with early-stage pancreatic cancer and that the effect might vary by individual statin agent.

Methods

We conducted a retrospective cohort study on data from an integrated healthcare system. We included patients with pancreatic cancer stage I-IIb who underwent resection for curative intent between January 2005 and January 2011. Baseline statin use was characterized as any prior use as well as active use of either simvastatin or lovastatin. Intensity of exposure was calculated as average daily dose prior to surgery. Overall and di

SUBMITTER: Wu BU 

PROVIDER: S-EPMC4877304 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature