Proinflammatory genotype is associated with the frailty phenotype in the English Longitudinal Study of Ageing.

ABSTRACT:

Background

Frailty is a state of increased vulnerability to poor resolution of homeostasis after a stressor event, which increases the risk of adverse outcomes including falls, disability and death. The underlying pathophysiological pathways of frailty are not known but the hypothalamic-pituitary-adrenal axis and heightened chronic systemic inflammation appear to be major contributors.

Methods

We used the English Longitudinal Study of Ageing dataset of 3160 individuals over the age of 50 and assessed their frailty status according to the Fried-criteria. We selected single nucleotide polymorphisms in genes involved in the steroid hormone or inflammatory pathways and performed linear association analysis using age and sex as covariates. To support the biological plausibility o

SUBMITTER: Mekli K 

PROVIDER: S-EPMC4877432 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature