Relevance of HLA-DP/DQ and ICAM-1 SNPs among Ovarian Cancer Patients.

ABSTRACT:

Background

Ovarian cancer is one of the most lethal gynecological malignancies and the fifth leading cause of cancer deaths among women. The high mortality rate is largely attributed to its diagnosis in advanced stages. Poor prognosis of ovarian cancer is usually due to the lack of specific or effective screening and diagnostic methods for identifying early-stage disease.

Aim

Our study aimed to study the role of HLA-DP, HLA-DQ, and ICAM-1 SNPs in diagnosis and/or prognosis of ovarian tumors.

Subjects and methods

The current study was conducted on 60 patients with ovarian tumors (benign, borderline, and malignant) and 20 healthy volunteers. Genotyping of HLA-DP rs3077, HLA-DQ rs3920, and ICAM-1 rs1437 SNPs was done using 5' nuclease assay.

Results

We found signi

SUBMITTER: Ghazy AA 

PROVIDER: S-EPMC4877515 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature