Triggering the adaptive immune system with commensal gut bacteria protects against insulin resistance and dysglycemia.

ABSTRACT:

Objective

To demonstrate that glycemia and insulin resistance are controlled by a mechanism involving the adaptive immune system and gut microbiota crosstalk.

Methods

We triggered the immune system with microbial extracts specifically from the intestinal ileum contents of HFD-diabetic mice by the process of immunization. 35 days later, immunized mice were fed a HFD for up to two months in order to challenge the development of metabolic features. The immune responses were quantified. Eventually, adoptive transfer of immune cells from the microbiota-immunized mice to naïve mice was performed to demonstrate the causality of the microbiota-stimulated adaptive immune system on the development of metabolic disease. The gut microbiota of the immunized HFD-fed mice was characterized

SUBMITTER: Pomie C 

PROVIDER: S-EPMC4877664 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature