The Dynamic Regulatory Genome of Capsaspora and the Origin of Animal Multicellularity.

ABSTRACT: The unicellular ancestor of animals had a complex repertoire of genes linked to multicellular processes. This suggests that changes in the regulatory genome, rather than in gene innovation, were key to the origin of animals. Here, we carry out multiple functional genomic assays in Capsaspora owczarzaki, the unicellular relative of animals with the largest known gene repertoire for transcriptional regulation. We show that changing chromatin states, differential lincRNA expression, and dynamic cis-regulatory sites are associated with life cycle transitions in Capsaspora. Moreover, we demonstrate conservation of animal developmental transcription-factor networks and extensive network interconnection in this premetazoan organism. In contrast, however, Capsaspora lacks animal promoter types, an

SUBMITTER: Sebe-Pedros A 

PROVIDER: S-EPMC4877666 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature