Association between Estrogen Receptor Alpha Gene Polymorphisms and Susceptibility to Idiopathic Scoliosis in Bulgarian Patients: A Case-Control Study.

ABSTRACT:

Background

The current consensus on idiopathic scoliosis maintains that it has a multifactorial etiology with genetic predisposing factors.

Aim

Estrogen receptor alpha gene has been considered as candidate gene of idiopathic scoliosis.

Material and methods

We conducted a case-control study of Bulgarian population samples (eighty patients with idiopathic scoliosis and one hundred-sixty healthy unrelated gender-matched controls) trying to investigate the association between common genetic polymorphisms of estrogen receptor alpha and the susceptibility to idiopathic scoliosis. Molecular detection of the restriction polymorphisms XbaI and PvuII was performed by polymerase chain reaction following by restriction fragment length polymorphism. The statistical analysis was pe

SUBMITTER: Nikolova S 

PROVIDER: S-EPMC4877867 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature