Noninvasive in vivo imaging of embryonic β-cell development in the anterior chamber of the eye.

ABSTRACT: The fetal environment plays a decisive role in modifying the risk for developing diabetes later in life. Developing novel methodology for noninvasive imaging of β-cell development in vivo under the controlled physiological conditions of the host can serve to understand how this environment affects β-cell growth and differentiation. A number of culture models have been designed for pancreatic rudiment but none match the complexity of the in utero or even normal physiological environment. Speier et al. recently developed a platform of noninvasive in vivo imaging of pancreatic islets using the anterior chamber of the eye where islets get vascularized, grow and respond to physiological changes. The same methodology was adapted for the study of pancreatic development. E13.0, still undifferentia

SUBMITTER: Cras-Meneur C 

PROVIDER: S-EPMC4878273 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature