Reducing Hepatocyte Injury and Necrosis in Response to Paracetamol Using Noncoding RNAs.

ABSTRACT:

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The liver performs multiple functions within the human body. It is composed of numerous cell types, which play important roles in organ physiology. Our study centers on the major metabolic cell type of the liver, the hepatocyte, and its susceptibility to damage during drug overdose. In these studies, hepatocytes were generated from a renewable and genetically defined resource. In vitro-derived hepatocytes were extensively profiled and exposed to varying levels of paracetamol and plasma isolated from liver-failure patients, with a view to identifying noncoding microRNAs that could reduce drug- or serum-induced hepatotoxicity. We identified a novel anti-microRNA, which reduced paracetamol-induced hepatotoxicity and glutathione depletion. Additionally, we identified a prosu

SUBMITTER: Szkolnicka D 

PROVIDER: S-EPMC4878326 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature