Identification of microRNA-mRNA interactions in atrial fibrillation using microarray expression profiles and bioinformatics analysis.

ABSTRACT: The present study integrated microRNA (miRNA) and mRNA expression data obtained from atrial fibrillation (AF) tissues and healthy tissues, in order to identify miRNAs and target genes that may be important in the development of AF. The GSE28954 miRNA expression profile and GSE2240 mRNA gene expression profile were downloaded from the Gene Expression Omnibus. Differentially expressed miRNAs and genes (DEGs) in AF tissues, compared with in control samples, were identified and hierarchically clustered. Subsequently, differentially expressed miRNAs and DEGs were searched for in the miRecords database and TarBase, and were used to construct a regulatory network using Cytoscape. Finally, functional analysis of the miRNA‑targeted genes was conducted. After data processing, 71 differentially expre

SUBMITTER: Wang T 

PROVIDER: S-EPMC4878535 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature