Construction and Experimental Validation of a Petri Net Model of Wnt/β-Catenin Signaling.

ABSTRACT: The Wnt/β-catenin signaling pathway is important for multiple developmental processes and tissue maintenance in adults. Consequently, deregulated signaling is involved in a range of human diseases including cancer and developmental defects. A better understanding of the intricate regulatory mechanism and effect of physiological (active) and pathophysiological (hyperactive) WNT signaling is important for predicting treatment response and developing novel therapies. The constitutively expressed CTNNB1 (commonly and hereafter referred to as β-catenin) is degraded by a destruction complex, composed of amongst others AXIN1 and GSK3. The destruction complex is inhibited during active WNT signaling, leading to β-catenin stabilization and induction of β-catenin/TCF target genes. In this study we i

SUBMITTER: Jacobsen A 

PROVIDER: S-EPMC4878796 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature