A tyrosine-reactive irreversible inhibitor for glutathione S-transferase Pi (GSTP1).

ABSTRACT: Glutathione S-transferase Pi (GSTP1) mediates cellular defense against reactive electrophiles. Here, we report LAS17, a dichlorotriazine-containing compound that irreversibly inhibits GSTP1 and is selective for GSTP1 within cellular proteomes. Mass spectrometry and mutational studies identified Y108 as the site of modification, providing a unique mode of GSTP1 inhibition.

SUBMITTER: Crawford LA 

PROVIDER: S-EPMC4879005 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature