Alpha2A adrenergic receptor genetic variation contributes to hyperglycemia after myocardial infarction.

ABSTRACT:

Background

Acute myocardial infarction (AMI) is frequently associated with transient hyperglycemia even in patients without pre-existing diabetes. Acute stress can lead to increased blood glucose through the effect of catecholamines on alpha2A-adrenergic receptors (α2A-ARs) present in pancreatic islet β-cells. Variation in the gene (ADRA2A) that encodes the α2A-AR affects insulin release and glucose control and may play a particularly important role during times of stress.

Methods

We performed a retrospective cohort study using de-identified electronic medical records linked to a DNA repository in 521 Caucasians and 55 African-American non-diabetic patients with AMI. We examined the association between admission blood glucose concentrations and ten selected ADRA2A SNPs in Ca

SUBMITTER: Adefurin A 

PROVIDER: S-EPMC4879094 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature