Linkage and association analysis of ADHD endophenotypes in extended and multigenerational pedigrees from a genetic isolate.

ABSTRACT: Attention-deficit/hyperactivity disorder (ADHD) is a heritable, chronic, neurodevelopmental disorder with serious long-term repercussions. Despite being one of the most common cognitive disorders, the clinical diagnosis of ADHD is based on subjective assessments of perceived behaviors. Endophenotypes (neurobiological markers that cosegregate and are associated with an illness) are thought to provide a more powerful and objective framework for revealing the underlying neurobiology than syndromic psychiatric classification. Here, we present the results of applying genetic linkage and association analyses to neuropsychological endophenotypes using microsatellite and single nucleotide polymorphisms. We found several new genetic regions linked and/or associated with these endophenotypes, and ot

SUBMITTER: Mastronardi CA 

PROVIDER: S-EPMC4879118 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature