Individual differences in orexin-I receptor modulation of motivation for the opioid remifentanil.

ABSTRACT: Orexin-1 receptors (Ox1Rs) have been implicated in the motivation for drugs of abuse. Here, we utilized a within-session behavioral-economics threshold procedure to screen for individual differences in economic demand for the ultra-short-acting opioid remifentanil and to test whether antagonism of Ox1Rs reduces remifentanil demand. The behavioral-economics procedure revealed robust individual differences in free consumption of remifentanil (Q₀ parameter; hedonic set point). Rats with low baseline Q₀ (low takers) displayed high demand elasticity (α parameter; reduced responding as drug price increased indicating low motivation for drug), whereas subjects with a higher Q₀ (high takers) exhibit low demand elasticity (low α) by continuing to self-administer rem

SUBMITTER: Porter-Stransky KA 

PROVIDER: S-EPMC4879120 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature