Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151).

ABSTRACT: People's differences in cognitive functions are partly heritable and are associated with important life outcomes. Previous genome-wide association (GWA) studies of cognitive functions have found evidence for polygenic effects yet, to date, there are few replicated genetic associations. Here we use data from the UK Biobank sample to investigate the genetic contributions to variation in tests of three cognitive functions and in educational attainment. GWA analyses were performed for verbal-numerical reasoning (N=36 035), memory (N=112 067), reaction time (N=111 483) and for the attainment of a college or a university degree (N=111 114). We report genome-wide significant single-nucleotide polymorphism (SNP)-based associations in 20 genomic regions, and significant gene-based findings in 46 re

SUBMITTER: Davies G 

PROVIDER: S-EPMC4879186 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature