Advanced Molecular Detection of Malarone Resistance.
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ABSTRACT:
SUBMITTER: Talundzic E
PROVIDER: S-EPMC4879379 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Advanced Molecular Detection of Malarone Resistance.
Talundzic Eldin E Plucinski Mateusz M MM Biliya Shweta S Silva-Flannery Luciana M LM Arguin Paul M PM Halsey Eric S ES Barnwell John W JW Vannberg Fredrik F Udhayakumar Venkatachalam V
Antimicrobial agents and chemotherapy 20160523 6
The rapid emergence of drug-resistant malaria parasites during the course of an infection remains a major challenge for providing accurate treatment guidelines. This is particularly important in cases of malaria treatment failure. Using a previously well-characterized case of malaria treatment failure, we show the utility of using next-generation sequencing for early detection of the rise and selection of a previously reported atovaquone-proguanil (malarone) drug resistance-associated mutation. ...[more]
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