Altered expression of Butyrophilin (BTN) and BTN-like (BTNL) genes in intestinal inflammation and colon cancer.

ABSTRACT: Several Butyrophilin (BTN) and Btn-like (BTNL) molecules control T lymphocyte responses, and are genetically associated with inflammatory disorders and cancer. In this study, we present a comprehensive expression analysis of human and murine BTN and BTNL genes in conditions associated with intestinal inflammation and cancer. Using real-time PCR, expression of human BTN and BTNL genes was analyzed in samples from patients with ulcerative colitis, irritable bowel syndrome, and colon tumors. Expression of murine Btn and Btnl genes was examined in mouse models of spontaneous colitis (Muc2^-/-) and intestinal tumorigenesis (Apc^Min/+). Our analysis indicates a strong association of several of the human genes with ulcera

SUBMITTER: Lebrero-Fernandez C 

PROVIDER: S-EPMC4879465 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature