Alterations in global DNA methylation and hydroxymethylation are not detected in Alzheimer's disease.

ABSTRACT:

Aims

Genetic factors do not seem to account fully for Alzheimer disease (AD) pathogenesis. There is evidence for the contribution of environmental factors, whose effect may be mediated by epigenetic mechanisms. Epigenetics involves the regulation of gene expression independently of DNA sequence and these epigenetic changes are influenced by age and environmental factors, with DNA methylation being one of the best characterized epigenetic mechanisms. The human genome is predominantly methylated on CpG motifs, which results in gene silencing; however methylation within the body of the gene may mark active transcription. There is evidence suggesting an involvement of environmental factors in the pathogenesis of Alzheimer's disease (AD), which prompted our study examining DNA methylati

SUBMITTER: Lashley T 

PROVIDER: S-EPMC4879505 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature