Effects of vascular risk factors, statins, and antihypertensive drugs on PiB deposition in cognitively normal subjects.

ABSTRACT:

Introduction

Hypertension, hypercholesterolemia, and obesity increase the risk of dementia. Although their detection is commonly followed by an introduction of treatment, little is known about how medications frequently used to treat vascular risk affect amyloid deposition.

Methods

A cross-sectional study of 156 subjects who underwent positron emission tomography with PiB. Using linear regression, we tested whether blood pressure, cholesterol, overweight/obese status, angiotensin receptor blockers (ARBs), beta-blockers, diuretics, angiotensin converting enzyme inhibitors, and statins predicted amyloid deposition.

Results

The use of ARBs (β = -.15, P = .044) and diuretics (β = -.20, P = .006) predicted less amyloid accumulation; older age (β = .29, P < .001) and statin

SUBMITTER: Glodzik L 

PROVIDER: S-EPMC4879519 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature