Unique spectral markers discern recurrent Glioblastoma cells from heterogeneous parent population.

ABSTRACT: An inability to discern resistant cells from bulk tumour cell population contributes to poor prognosis in Glioblastoma. Here, we compared parent and recurrent cells generated from patient derived primary cultures and cell lines to identify their unique molecular hallmarks. Although morphologically similar, parent and recurrent cells from different samples showed variable biological properties like proliferation and radiation resistance. However, total RNA-sequencing revealed transcriptional landscape unique to parent and recurrent populations. These data suggest that global molecular differences but not individual biological phenotype could differentiate parent and recurrent cells. We demonstrate that Raman Spectroscopy a label-free, non-invasive technique, yields global information about

SUBMITTER: Kaur E 

PROVIDER: S-EPMC4879554 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature