Repeated systemic inflammation was associated with cognitive deficits in older Britons.

ABSTRACT:

Introduction

The relationship of C-reactive protein (CRP) to cognition in the older old group (≥75 years) has recently been found positive on both sides of the Atlantic. We hypothesized that higher levels of CRP and fibrinogen are related to worse episodic memory throughout later life (≥50 years).

Methods

Data are drawn from older Britons free of dementias in the English Longitudinal Study of Aging 2004-2013. We applied growth trajectory models to repeated observations of episodic memory, CRP, and fibrinogen levels (and sociodemographic confounders). We accounted for practice effects in repeated tests of cognition.

Results

Higher levels of both inflammatory markers were associated with worse episodic memory, where a fibrinogen effect is evident throughout later life (

SUBMITTER: Tampubolon G 

PROVIDER: S-EPMC4879642 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature