MicroRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer's disease.

ABSTRACT:

Introduction

Mononuclear phagocytes play a critical role during Alzheimer's disease (AD) pathogenesis due to their contribution to innate immune responses and amyloid beta (Aβ) clearance mechanisms.

Methods

Blood-derived monocytes (BDMs) and monocyte-derived macrophages (MDMs) were isolated from blood of AD, mild cognitive impairment (MCI) patients, and age-matched healthy controls for molecular and phenotypic comparisons.

Results

The chemokine/chemokine receptor CCL2/CCR2 axis was impaired in BDMs from AD and MCI patients, causing a deficit in cell migration. Changes were also observed in MDM-mediated phagocytosis of Aβ fibrils, correlating with alterations in the expression and processing of the triggering receptor expressed on myeloid cells 2 (TREM2). Finally, immu

SUBMITTER: Guedes JR 

PROVIDER: S-EPMC4879648 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature