Thrombopoietin is associated with δ's intercept, and only in Non-Hispanic Whites.

ABSTRACT:

Introduction

Serum thrombopoietin (THPO) is a biomarker of Alzheimer's disease (AD) and the latent dementia phenotype, "δ". Both associations may be specific to non-Hispanic whites (NHW), not Mexican-Americans (MA). In this analysis, we examine ethnicity's effect on THPO's association with change in δ scores, in the Texas Alzheimer's Research and Care Consortium (TARCC).

Methods

We constructed an ethnicity equivalent δ homolog ("dEQ") among n = 1113 MA and n = 1958 NHW. dEQ was output as a composite "dEQ-score" for each of five annual TARCC waves. Those composites were used as indicators of a latent growth curve (LGC). The mean dEQ intercept (idEQ) and slope (ΔdEQ) were estimated in a random subset of N = 1528 participants and replicated in the remainder (n = 1544). THPO was

SUBMITTER: Royall DR 

PROVIDER: S-EPMC4879650 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature