A novel species of torque teno mini virus (TTMV) in gingival tissue from chronic periodontitis patients.

ABSTRACT: A new species of torque teno mini virus, named TTMV-222, was detected in gingival tissue from periodontitis patients using a viral metagenomics method. The 2803-nucleotide genome of TTMV-222 is closely related to TTMV1-CBD279, with 62.6% overall nucleotide similarity. Genetic analyses of the new virus genome revealed a classic genomic organization but a weak identity with known sequences. The prevalence of TTMV-222 in the periodontitis group (n = 150) was significantly higher than that in the healthy group (n = 150) (p = 0.032), suggesting that the new virus may be associated with inflammation in chronic periodontitis patients. However, this finding requires further investigation.

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC4879676 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature