Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study.

ABSTRACT:

Background

It has been reported that the composition of human gut microbiota changes with age; however, few studies have used molecular techniques to investigate the long-term, sequential changes in gut microbiota composition. In this study, we investigated the sequential changes in gut microbiota composition in newborn to centenarian Japanese subjects.

Results

Fecal samples from 367 healthy Japanese subjects between the ages of 0 and 104 years were analyzed by high-throughput sequencing of amplicons derived from the V3-V4 region of the 16S rRNA gene. Analysis based on bacterial co-abundance groups (CAGs) defined by Kendall correlations between genera revealed that certain transition types of microbiota were enriched in infants, adults, elderly individuals and both infant an

SUBMITTER: Odamaki T 

PROVIDER: S-EPMC4879732 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature