Brain trauma elicits non-canonical macrophage activation states.

ABSTRACT:

Background

Macrophage polarization programs, commonly referred to as "classical" and "alternative" activation, are widely considered as distinct states that are exclusive of one another and are associated with different functions such as inflammation and wound healing, respectively. In a number of disease contexts, such as traumatic brain injury (TBI), macrophage polarization influences the extent of pathogenesis, and efforts are underway to eliminate pathogenic subsets. However, previous studies have not distinguished whether the simultaneous presence of both classical and alternative activation signatures represents the admixture of differentially polarized macrophages or if they have adopted a unique state characterized by components of both classical and alternative activation.

SUBMITTER: Kim CC 

PROVIDER: S-EPMC4879757 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature