Linking Genes to Cardiovascular Diseases: Gene Action and Gene-Environment Interactions.

ABSTRACT: A unique myocardial characteristic is its ability to grow/remodel in order to adapt; this is determined partly by genes and partly by the environment and the milieu intérieur. In the "post-genomic" era, a need is emerging to elucidate the physiologic functions of myocardial genes, as well as potential adaptive and maladaptive modulations induced by environmental/epigenetic factors. Genome sequencing and analysis advances have become exponential lately, with escalation of our knowledge concerning sometimes controversial genetic underpinnings of cardiovascular diseases. Current technologies can identify candidate genes variously involved in diverse normal/abnormal morphomechanical phenotypes, and offer insights into multiple genetic factors implicated in complex cardiovascular syndromes. The

SUBMITTER: Pasipoularides A 

PROVIDER: S-EPMC4880019 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature