Incidence and prognostic impact of other cancers in a population of long-term survivors of chronic lymphocytic leukemia.

ABSTRACT:

Background

Information on the impact of other cancers (OCs) in long-term survivors (LTSs) of chronic lymphocytic leukemia (CLL) is limited.

Patients and methods

Patients with CLL who survived >10 years were defined as LTSs of CLL. We calculated standardized incidence ratios (SIRs) to compare the incidence of OC in LTS of CLL versus the general population. A multivariable model was used to identify independent predictors of OC. Overall survival was analyzed as a function of the presence of OC.

Results

Among 797 LTSs of CLL, the cumulative frequency of OC was 36%, similar between 570 patients (72%) who required treatment for CLL (TRT) and 227 (28%) who remained untreated (UT). The most common OC in both groups was non-melanoma skin cancer, followed by prostate cancer, b

SUBMITTER: Falchi L 

PROVIDER: S-EPMC4880062 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature