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Experimental Infection and Response to Rechallenge of Alpacas with Middle East Respiratory Syndrome Coronavirus.

ABSTRACT: We conducted a challenge/rechallenge trial in which 3 alpacas were infected with Middle East respiratory syndrome coronavirus. The alpacas shed virus at challenge but were refractory to further shedding at rechallenge on day 21. The trial indicates that alpacas may be suitable models for infection and shedding dynamics of this virus.

SUBMITTER: Crameri G

PROVIDER: S-EPMC4880109 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Experimental Infection and Response to Rechallenge of Alpacas with Middle East Respiratory Syndrome Coronavirus.

Crameri Gary G Durr Peter A PA Klein Reuben R Foord Adam A Yu Meng M Riddell Sarah S Haining Jessica J Johnson Dayna D Hemida Maged G MG Barr Jennifer J Peiris Malik M Middleton Deborah D Wang Lin-Fa LF

Emerging infectious diseases 20160615 6

We conducted a challenge/rechallenge trial in which 3 alpacas were infected with Middle East respiratory syndrome coronavirus. The alpacas shed virus at challenge but were refractory to further shedding at rechallenge on day 21. The trial indicates that alpacas may be suitable models for infection and shedding dynamics of this virus. ...[more]

PMID: 27070733

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