Vitamin D Supplementation Modulates T Cell-Mediated Immunity in Humans: Results from a Randomized Control Trial.

ABSTRACT:

Context

Although studies have linked vitamin D deficiency with immune-mediated diseases, data demonstrating a direct effect on T-cell function are sparse.

Objective

Our objective was to determine whether oral vitamin D3 influences T-cell activation in humans with vitamin D deficiency.

Design

This was a single-center ancillary study within Vitamin D Therapy in Individuals at High Risk of Hypertension, a double-blind, multicenter, randomized controlled trial.

Setting

This study was undertaken in a single academic medical center.

Participants

Adults with vitamin D deficiency and untreated pre- or early stage I hypertension were included.

Intervention

In Vitamin D Therapy in Individuals at High Risk of Hypertension, participants were randomized to eit

SUBMITTER: Konijeti GG 

PROVIDER: S-EPMC4880125 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature