Effects of Gastric Bypass and Gastric Banding on Bone Remodeling in Obese Patients With Type 2 Diabetes.

ABSTRACT:

Context

Roux-en-Y gastric bypass (RYGB) leads to high-turnover bone loss, but little is known about skeletal effects of laparoscopic adjustable gastric banding (LAGB) or mechanisms underlying bone loss after bariatric surgery.

Objective

To evaluate effects of RYGB and LAGB on fasting and postprandial indices of bone remodeling.

Design and setting

Ancillary investigation of a prospective study at 2 academic institutions.

Participants

Obese adults aged 21-65 years with type 2 diabetes who underwent RYGB (n = 11) or LAGB (n = 8).

Outcomes

Serum C-terminal telopeptide (CTX), procollagen type 1 N-terminal propeptide (P1NP), and PTH were measured during a mixed meal tolerance test at baseline, 10 days and 1 year after surgery. Changes in 25-hydroxyvitamin D, p

SUBMITTER: Yu EW 

PROVIDER: S-EPMC4880129 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature