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Differential Effects of Teriparatide and Denosumab on Intact PTH and Bone Formation Indices: AVA Osteoporosis Study.

ABSTRACT: We compared effects of teriparatide and denosumab on PTH, bone turnover markers, and bone histomorphometry in osteoporotic postmenopausal women. The findings were inconsistent with an early indirect anabolic effect of denosumab.

SUBMITTER: Dempster DW 

PROVIDER: S-EPMC4880160 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Differential Effects of Teriparatide and Denosumab on Intact PTH and Bone Formation Indices: AVA Osteoporosis Study.

Dempster David W DW   Zhou Hua H   Recker Robert R RR   Brown Jacques P JP   Recknor Christopher P CP   Lewiecki E Michael EM   Miller Paul D PD   Rao Sudhaker D SD   Kendler David L DL   Lindsay Robert R   Krege John H JH   Alam Jahangir J   Taylor Kathleen A KA   Janos Boris B   Ruff Valerie A VA  

The Journal of clinical endocrinology and metabolism 20160209 4

We compared effects of teriparatide and denosumab on PTH, bone turnover markers, and bone histomorphometry in osteoporotic postmenopausal women. The findings were inconsistent with an early indirect anabolic effect of denosumab. ...[more]

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