Effect of Leptin Administration on Circulating Apolipoprotein CIII levels in Patients With Lipodystrophy.

ABSTRACT:

Context

Apolipoprotein CIII (apoCIII), an inhibitor of lipoprotein lipase, plays an important role in triglyceride metabolism. However, the role of apoCIII in hypertriglyceridemia in lipodystrophy and the effects of leptin replacement on apoCIII levels are unknown.

Objective

The objective of the study was to test the hypotheses that apoCIII is elevated in hypertriglyceridemic patients with lipodystrophy and that leptin replacement in these patients lowers circulating apoCIII.

Design, setting, study participants, intervention, and outcome measures

Using a post hoc cross-sectional case-control design, we compared serum apoCIII levels from patients with lipodystrophy not associated with HIV (n = 60) and age-, gender-, race-, and ethnicity-matched controls (n = 54) partic

SUBMITTER: Kassai A 

PROVIDER: S-EPMC4880162 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature