Vitamin D Supplementation Does Not Impact Insulin Resistance in Black and White Children.

ABSTRACT:

Context

Vitamin D supplementation trials with diabetes-related outcomes have been conducted almost exclusively in adults and provide equivocal findings.

Objective

The objective of this study was to determine the dose-response of vitamin D supplementation on fasting glucose, insulin, and a surrogate measure of insulin resistance in white and black children aged 9–13 years, who participated in the Georgia, Purdue, and Indiana University (or GAPI) trial: a 12-week multisite, randomized, triple-masked, dose-response, placebo-controlled vitamin D trial.

Design

Black and white children in the early stages of puberty (N = 323, 50% male, 51% black) were equally randomized to receive vitamin D3 (0, 400, 1000, 2000, or 4000 IU/day) for 12 weeks. Fasting serum 25-hydroxyvitamin

SUBMITTER: Ferira AJ 

PROVIDER: S-EPMC4880166 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature